@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RA0UFXrlBNciWJp7kKelPDD3ZvmW6fpjsaBKB0m_YNuDM> .
@prefix sub: <http://purl.org/np/RA0UFXrlBNciWJp7kKelPDD3ZvmW6fpjsaBKB0m_YNuDM#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_5844> biolink:category biolink:Disease .
  
  sub:association a rdf:Statement;
    rdf:object <http://purl.obolibrary.org/obo/DOID_5844>;
    rdf:predicate biolink:treats;
    rdf:subject <https://identifiers.org/drugbank:DB01079>;
    rdfs:label "\"ZELNORM is contraindicated in patients with:     A history of myocardial infarction (MI), stroke, transient ischemic attack (TIA), or angina  [see  Warnings and Precautions (5.1)   A history of ischemic colitis or other forms of intestinal ischemia  [see  Warnings and Precautions (5.2) Severe renal impairment (eGFR< 15 mL/min/1.73 m 2 [see  Use in Specific Populations (8.6) Moderate and severe hepatic impairment (Child-Pugh B or C)  [see  Use in Specific Populations (8.7) A history of bowel obstruction, symptomatic gallbladder disease, suspected sphincter of Oddi dysfunction, or abdominal adhesions  [see  Adverse Reactions (6.2) Hypersensitivity to tegaserod  [see  Adverse Reactions (6.2) ZELNORM is contraindicated in patients with:   A history of myocardial infarction, stroke, transient ischemic attack, or angina. ( 4 5.1 A history of ischemic colitis or other forms of intestinal ischemia. ( 4 5.2 Severe renal impairment (eGFR< 15 mL/min/1.73 m 2 4 8.6 Moderate or severe hepatic impairment (Child-Pugh B or C). ( 4 8.7 A history of bowel obstruction, symptomatic gallbladder disease, suspected sphincter of Oddi dysfunction, or abdominal adhesions. ( 4 Hypersensitivity to tegaserod. ( 4\"";
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:relation schema:MedicalContraindication .
  
  <https://identifiers.org/drugbank:DB01079> biolink:category biolink:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB";
    npx:hasSignature "HMpAN/ZLAiirJ0dlGD2UuaPZ7LKEBwrf2JA4ZsjRPcg2IJ0rov5ynpWH9odQraW2JKDIExFrpyJqG7XB53q9ysnb6ceOxqO1r1BhZH20ivER7b12CBzWRThwvtaYTJxibEkRo5mG6J7G2XX+oPaTclLx92lBGH8NkaFT7RTPUhI=";
    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-08-23T19:01:06.583+02:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-1468-3557;
    ns1:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    ns1:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}