@prefix this: <https://w3id.org/np/RAMnmRXF9VVk48fasiZbu-gB7cdFafVwWbJbDv3iW7C7M> .
@prefix sub: <https://w3id.org/np/RAMnmRXF9VVk48fasiZbu-gB7cdFafVwWbJbDv3iW7C7M/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix mvikg: <http://example.org/mvikg/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix sosa: <http://www.w3.org/ns/sosa/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  <https://w3id.org/np/RA34_jToFXNCTchMWIf1Ap6lwZRXWv5fsEJuq-9qo9wzg/variant> a <http://purl.obolibrary.org/obo/SO_0000694>,
      biolink:SequenceVariant;
    mvikg:alt "Val";
    mvikg:effect "decamer-stabilizing mutation; increased conformational stability in most regions except the active site loop and resolving cysteine region";
    mvikg:evidenceText "the T77V mutation resulted in an increase in conformational stability in most regions of the protein except for the active site loop and the region encompassing the resolving cysteine";
    mvikg:ref "Thr";
    dct:isPartOf <https://w3id.org/spaces/mvikg/r/kg>;
    rdfs:comment "T77V";
    rdfs:label "PMC3079231-Salmonella_typhimurium-variant2";
    biolink:start_coordinate "77"^^xsd:integer .
  
  <https://www.ncbi.nlm.nih.gov/gene/1252128> a biolink:Gene;
    sosa:isFeatureOfInterestOf <https://w3id.org/np/RAsleYmeoDiAB_oH3EJuVb_Hisg0vVQHBHZFP1IkjKfIk/sample>;
    biolink:has_sequence_variant <https://w3id.org/np/RA34_jToFXNCTchMWIf1Ap6lwZRXWv5fsEJuq-9qo9wzg/variant> .
}

sub:provenance {
  sub:assertion prov:wasDerivedFrom <https://w3id.org/mvikg/abox#VARIANT-VAR_002-1252128> .
}

sub:pubinfo {
  this: dct:created "2026-11-10T10:34:58Z"^^xsd:dateTime;
    dct:creator orcid:0009-0005-5515-1230;
    dct:license <https://creativecommons.org/licenses/by/4.0/>;
    npx:introduces <https://w3id.org/np/RA34_jToFXNCTchMWIf1Ap6lwZRXWv5fsEJuq-9qo9wzg/variant>;
    npx:supersedes <https://w3id.org/np/RApbvHfMaJcMmu9MkmsMVgQ-ZHN6lDZGCScnlF56xDF0o>;
    skos:changeNote "Adds the change note that was missing from the immediately preceding version (which corrected the provenance/pubinfo template links and stabilized npx:introduces).";
    nt:wasCreatedFromProvenanceTemplate <https://w3id.org/np/RAHKGU7g81YLKWl0S7g0oKdiRD5LhcPFMjVkAgLnipR_g>;
    nt:wasCreatedFromPubinfoTemplate <https://w3id.org/np/RA-N4_kFxcruvBTlo1yJv29E4SLOXsx5KO_th69PprMrA>,
      <https://w3id.org/np/RACJ58Gvyn91LqCKIO9zu1eijDQIeEff28iyDrJgjSJF8>, <https://w3id.org/np/RAKc76yHLDbloE6ObluzYQsfX37v6qrZXbYeIKpe8-YUo>,
      <https://w3id.org/np/RAoTD7udB2KtUuOuAe74tJi1t3VzK0DyWS7rYVAq1GRvw>;
    nt:wasCreatedFromTemplate <https://w3id.org/np/RAnlONjGChImRjDeXxTwrTmndhfv1guES7EnXlp1CaE3g/templateVersion> .
  
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIIBIjANBgkqhkiG9w0BAQEFAAOCAQ8AMIIBCgKCAQEAjO3oH8Lq/l1oZIUY3FlCz5DnndybGvAhBdmEJ/yq7Nv3GZEYPrEro23rCBCp0GiriOXlVbk61pA/7JFE6tqzTresINW6QQMxE9sIhCBlX4cG66JFD8ud6bMvUyzCR8LQA6zfrSbafGE06rvglJd4MDUcTwvUKqtL9UCnOaowVfnZ3sPOe9EqlmJuO3iHGxBSXMPOPEJZUzMXsFDWFuMZTnrR8gY3r5nVF5a8L/MD135ZH8qW5yGXOB28CmVYCAbw2o07QEKzyzFKN+W1gfnprYZvuKzwGexnzcdzc1S8N/M5bzhWQ40EKCEqgUE8c81OzEMm1HUlUKEJ/o5I/FKKAwIDAQAB";
    npx:hasSignature "C4Y4+5uCJFVjFlFYjSj/nN0i7UpJRSfhOPcQ+r4xkw4csGNcBGoSMo9+Nn9BdYUwEAv4Kucp1r6vTpMAInpzsNEdKQ18hMZCayXHGwKVn5HfYRlBsqJgLdO4PZhNQpjgHvrdWvEtocIYi4crjMTPjGzA9G58HEQHzWHmZsxlJNAaWDmbgmv2TQtxz+H2kPxacWCyOnQEOMPo75sdRwYUDfZnMXUSnv8QTG7mSbpL1O83KQQEYfeBGkGsG77rEixl67ihvfo3T/I+Ba0M7sYb2x7eHrNgf+14C2is0AZ4d5IOelPgO07Vd3A2MJnPstQ1PCq+V93BfiZE3zeexnuhdA==";
    npx:hasSignatureTarget this:;
    npx:signedBy orcid:0009-0005-5515-1230 .
}