@prefix this: <https://w3id.org/np/RAQpPfkWICBsbPg7rKtlwvdZAqXlrKVKEMY5Lhf5y-zSM> .
@prefix sub: <https://w3id.org/np/RAQpPfkWICBsbPg7rKtlwvdZAqXlrKVKEMY5Lhf5y-zSM/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix mvikg: <http://example.org/mvikg/> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix sosa: <http://www.w3.org/ns/sosa/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  sub:variant a <http://purl.obolibrary.org/obo/SO_SO:0000694>, biolink:SequenceVariant;
    mvikg:alt "Val";
    mvikg:effect "decamer-stabilizing mutation; increased conformational stability in most regions except the active site loop and resolving cysteine region";
    mvikg:evidenceText "the T77V mutation resulted in an increase in conformational stability in most regions of the protein except for the active site loop and the region encompassing the resolving cysteine";
    mvikg:ref "Thr";
    dct:isPartOf <https://w3id.org/spaces/mvikg/r/kg>;
    rdfs:label "T77V";
    biolink:start_coordinate "77"^^xsd:integer .
  
  <https://www.ncbi.nlm.nih.gov/gene/1252128> a biolink:Gene;
    sosa:isFeatureOfInterestOf <https://w3id.org/np/RAsleYmeoDiAB_oH3EJuVb_Hisg0vVQHBHZFP1IkjKfIk/sample>;
    biolink:has_sequence_variant sub:variant .
}

sub:provenance {
  sub:assertion prov:wasDerivedFrom <https://w3id.org/mvikg/abox#VARIANT-VAR_002-1252128> .
}

sub:pubinfo {
  this: dct:created "2026-11-09T08:50:51Z"^^xsd:dateTime;
    dct:creator orcid:0009-0005-5515-1230;
    dct:license <https://creativecommons.org/licenses/by/4.0/>;
    npx:introduces sub:variant;
    rdfs:label "T77V";
    nt:wasCreatedFromProvenanceTemplate <https://w3id.org/np/RA-yPZEYODCS39dWOWm7NA_ClOGFHzPi8iYhLzoZf19GI>;
    nt:wasCreatedFromPubinfoTemplate <https://w3id.org/np/RA4o9JqSxNO2Z47itbAcxvpVfdR97t_7usxmdR90URXQs>;
    nt:wasCreatedFromTemplate <https://w3id.org/np/RAnlONjGChImRjDeXxTwrTmndhfv1guES7EnXlp1CaE3g/templateVersion> .
  
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIIBIjANBgkqhkiG9w0BAQEFAAOCAQ8AMIIBCgKCAQEAjO3oH8Lq/l1oZIUY3FlCz5DnndybGvAhBdmEJ/yq7Nv3GZEYPrEro23rCBCp0GiriOXlVbk61pA/7JFE6tqzTresINW6QQMxE9sIhCBlX4cG66JFD8ud6bMvUyzCR8LQA6zfrSbafGE06rvglJd4MDUcTwvUKqtL9UCnOaowVfnZ3sPOe9EqlmJuO3iHGxBSXMPOPEJZUzMXsFDWFuMZTnrR8gY3r5nVF5a8L/MD135ZH8qW5yGXOB28CmVYCAbw2o07QEKzyzFKN+W1gfnprYZvuKzwGexnzcdzc1S8N/M5bzhWQ40EKCEqgUE8c81OzEMm1HUlUKEJ/o5I/FKKAwIDAQAB";
    npx:hasSignature "Y4x1hiI6u6qqxfwnSD6pL4Nda00rl6IX6ZkWlCPDbCbaHTQRio/eKrWndqxQpOkWf6/PCxJzqfyoJYNIs8ElZi3vD2DHgNi9Yxm0ICyJJAtUCGGofOrXa7bnRQeQXqovhCg3SLAin2T7J2WdFTkN+XJpAozT5Tmw4cGOMjcmeb6eAVIelcQlE65z6X8d4QQurjz9SWlZ3Npf9CNIQBZaczpgvXdrMbKVdXB/asXLsyLKIcSKbQyQutH7Lq/Fh2NDtJ+o/qoMPTu9JjiXiRd6NTEsqF2QVQPMLKe0uLLpTB3AQlyaju9DWESblwyJV8ZEmX9Gom8MNJmJAuKp1cEeWQ==";
    npx:hasSignatureTarget this:;
    npx:signedBy orcid:0009-0005-5515-1230 .
}