@prefix ns1: <http://purl.org/dc/terms/> .
@prefix this: <http://purl.org/np/RARBFKSjSb07s9AkXybAc937ia55iC2CAJrhrhQ7NDgJk> .
@prefix sub: <http://purl.org/np/RARBFKSjSb07s9AkXybAc937ia55iC2CAJrhrhQ7NDgJk#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix schema: <https://schema.org/> .
@prefix nkg: <https://w3id.org/neurodkg/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  sub:assertion a nt:AssertionTemplate;
    rdfs:label "Defining a drug indication with its medical context";
    nt:hasStatement sub:st00, sub:st01, sub:st02, sub:st03, sub:st04, sub:st05, sub:st06,
      sub:st07, sub:st08, sub:st09 .
  
  sub:audienceType a nt:LiteralPlaceholder;
    rdfs:label "has the target group (eg. adult, pregnant)" .
  
  sub:condition a nt:GuidedChoicePlaceholder;
    rdfs:label "define the condition for target population using DOID";
    nt:possibleValuesFromApi "http://data.bioontology.org/search?pagesize=20&apikey=fd451bec-eacd-4519-b972-90fb6c7007cb&include_properties=false&ontologies=DOID&q=" .
  
  sub:disease a nt:GuidedChoicePlaceholder;
    rdfs:label "has disease using DOID";
    nt:possibleValuesFromApi "http://data.bioontology.org/search?pagesize=20&apikey=fd451bec-eacd-4519-b972-90fb6c7007cb&include_properties=false&ontologies=DOID&q=" .
  
  sub:drug a nt:UriPlaceholder;
    rdfs:label "add a Drugbank identifier here (e.g. DB00295)";
    nt:hasPrefix "http://identifiers.org/drugbank/";
    nt:hasPrefixLabel " has the drug";
    nt:hasRegex "[DB]\\d{5}" .
  
  sub:indi_type a nt:GuidedChoicePlaceholder;
    rdfs:label "add the indication type for medical therapy";
    nt:possibleValue schema:ApprovedIndication, schema:PreventionIndication, schema:TreatmentIndication,
      nkg:AdjunctiveTherapy, nkg:SymptomaticReliefIndication .
  
  sub:maxAge a nt:LiteralPlaceholder;
    rdfs:label "Audiences defined by a person's maximum age.";
    nt:hasRegex "[0-9]*" .
  
  sub:medtherapy a nt:LocalResource;
    rdfs:label "This medical therapy " .
  
  sub:minAge a nt:LiteralPlaceholder;
    rdfs:label "Audiences defined by a person's minimum age.";
    nt:hasRegex "[0-9]*" .
  
  sub:quotedtext a nt:LiteralPlaceholder;
    rdfs:label "add a quote here" .
  
  sub:st00 a rdf:Statement;
    rdf:object sub:quotedtext;
    rdf:predicate prov:quotedText;
    rdf:subject sub:medtherapy;
    nt:statementOrder "1"^^xsd:integer .
  
  sub:st01 a rdf:Statement;
    rdf:object sub:drug;
    rdf:predicate schema:drug;
    rdf:subject sub:medtherapy;
    nt:statementOrder "2"^^xsd:integer .
  
  sub:st02 a rdf:Statement;
    rdf:object sub:medtherapy;
    rdf:predicate schema:possibleTreatment;
    rdf:subject sub:disease;
    nt:statementOrder "3"^^xsd:integer .
  
  sub:st03 a rdf:Statement;
    rdf:object sub:indi_type;
    rdf:predicate nkg:indicationType;
    rdf:subject sub:medtherapy;
    nt:statementOrder "4"^^xsd:integer .
  
  sub:st04 a rdf:Statement;
    rdf:object sub:targetpop;
    rdf:predicate schema:targtePopulation;
    rdf:subject sub:medtherapy;
    nt:statementOrder "5"^^xsd:integer .
  
  sub:st05 a rdf:Statement, nt:OptionalStatement;
    rdf:object sub:audienceType;
    rdf:predicate schema:audienceType;
    rdf:subject sub:targetpop;
    nt:statementOrder "6"^^xsd:integer .
  
  sub:st06 a rdf:Statement, nt:OptionalStatement;
    rdf:object sub:minAge;
    rdf:predicate schema:requiredMinAge;
    rdf:subject sub:targetpop;
    nt:statementOrder "7"^^xsd:integer .
  
  sub:st07 a rdf:Statement, nt:OptionalStatement;
    rdf:object sub:maxAge;
    rdf:predicate schema:requiredMaxAge;
    rdf:subject sub:targetpop;
    nt:statementOrder "8"^^xsd:integer .
  
  sub:st08 a rdf:Statement, nt:OptionalStatement;
    rdf:object sub:condition;
    rdf:predicate schema:healthCondition;
    rdf:subject sub:targetpop;
    nt:statementOrder "9"^^xsd:integer .
  
  sub:st09 a rdf:Statement, nt:OptionalStatement;
    rdf:object sub:symptom;
    rdf:predicate nkg:hasSymptom;
    rdf:subject sub:targetpop;
    nt:statementOrder "10"^^xsd:integer .
  
  sub:symptom a nt:GuidedChoicePlaceholder;
    rdfs:label "target biomedical entity from Translator NameResolution API";
    nt:possibleValuesFromApi "https://name-resolution-sri.renci.org/lookup?limit=10&string=" .
  
  sub:targetpop a nt:LocalResource;
    rdfs:label "has the target population" .
  
  prov:quotedText rdfs:label "claims" .
  
  schema:ApprovedIndication rdfs:label "An indication for a medical therapy that has been formally specified or approved by a regulatory body." .
  
  schema:PreventionIndication rdfs:label "An indication for preventing an underlying condition, symptom, etc." .
  
  schema:TreatmentIndication rdfs:label "An indication for treating an underlying condition." .
  
  nkg:SymptomaticReliefIndication rdfs:label "An indication for only managing the symptoms of the condition" .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0001-7769-4272 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCOqbrPT5RmzxsvRXGHZSAXPzeRLt9ogiosL3tcPKC0g5J8B1577lnJ3oVKSfD80lgPJdr9K671RazGL/mkZ/yu/uCNqne07Q9jd6OIAEi3fldiVfGK8ZDh43rGWRuG+BlvbZ1lZRFrWsURTKTpMgh0C6vJFRIMkWH6ImbZC5JbbQIDAQAB";
    npx:hasSignature "Q2mthgg7SLfv0OKnEKD43jst9EfVJqRvfEq3IVMvg+8Ru8hdYeoR/oppDH9yBAlQLybryXoBt7zI+NSbuS1ZEu5sp/3H/UfkU7vbmS+P/eYLY3Pt8TBDkObPJDb5drnC/PXjakY/NwtP4DoiaGDKU84MTaOkei3cqbCfO2bhpOY=";
    npx:hasSignatureTarget this: .
  
  this: ns1:created "2020-12-07T18:00:00.000+01:00"^^xsd:dateTime;
    ns1:creator orcid:0000-0001-7769-4272;
    npx:supercedes <http://purl.org/np/RAskqjj-YM6iTe-EhzxoSiVC-b9awUfI1y-uQE2q0ZEVI> .
}