@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RAXpQdI1ynPAyJ2Dt46RGOvuW96CzHLCDM4hcqROJ_QBQ> .
@prefix sub: <http://purl.org/np/RAXpQdI1ynPAyJ2Dt46RGOvuW96CzHLCDM4hcqROJ_QBQ#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix mondo: <http://purl.obolibrary.org/obo/MONDO_> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo .
}

sub:assertion {
  drugbank:DB00540 a biolink:Drug;
    rdfs:label "Nortriptyline";
    biolink:category biolink:Drug .
  
  mondo:0005277 a biolink:Disease;
    rdfs:label "Migraine (disorder)";
    biolink:category biolink:Disease .
  
  sub:association a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    rdf:object mondo:0005277;
    rdf:predicate biolink:treats;
    rdf:subject drugbank:DB00540;
    rdfs:label "Although antidepressants are not the first-line prophylactic strategy for patients with migraine, several clinical trials have proven their effectiveness in the treatment of migraine and related headache disorders (Koch and Jurgens, 2009). Especially TCAs: amitriptyline (Couch and Hassanein, 1979; Jackson et al., 2010; Kalita et al., 2013) and nortriptyline (Holroyd et al., 2001; Jackson et al., 2010) have the best evidence for use in migraine prevention. When amitriptyline is not tolerated by patients, treatment is continued with nortriptyline (Burch, 2019).";
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
    biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:context;
    biolink:publications pmid:31622593;
    biolink:relation ncit:C94303 .
  
  sub:context a biolink:Cohort;
    rdfs:label "Adults";
    biolink:category biolink:Cohort .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
    npx:hasSignature "WDU8Md7fxzgBpkzDV753+0oW02Pg654pxXTHQUuSzslYR+sqXZJrr2159QyAbwPHaoCSrmgeM83D81ARdnn4MeD0lM2mnDlYWvWWycRzLHVOl7dtBeh9h3xOHvcSv3jEvw3In0ZR0J9uxxzqkP53AFopVepGKodMTk0TCFSgJmc=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2022-09-16T11:48:57.309432"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-1501-1082;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
  
  biolink: pav:version "2.3.0" .
}