@prefix this: <https://w3id.org/np/RA_CvFq8xqODYIpo_NrYBgrjawd0vqCjayLt0TyBCccGM> .
@prefix sub: <https://w3id.org/np/RA_CvFq8xqODYIpo_NrYBgrjawd0vqCjayLt0TyBCccGM/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix mvikg: <http://example.org/mvikg/> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix sosa: <http://www.w3.org/ns/sosa/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  sub:variant a <http://purl.obolibrary.org/obo/SO_0001059>, biolink:SequenceVariant;
    mvikg:effect "impaired replication in macrophages; ~40% co-localization with lysosomal marker TROva vs ~15% for wild-type; complemented by pBADphoP";
    mvikg:evidenceText "Growth of both 12023 and the LT2 phoP mutant strain was restored, and the percentage of mutant bacteria that co-localized with TROva reduced from approximately 40 to 20 %, by the expression of phoP from pBADphoP";
    dct:isPartOf <https://w3id.org/spaces/mvikg/r/kg>;
    rdfs:comment "VAR_001";
    rdfs:label "PMC3167890-S._Typhimurium_LT2_phoP_null_mutant-variant2" .
  
  <https://www.uniprot.org/uniprot/P0DM78> a biolink:Gene;
    sosa:isFeatureOfInterestOf <https://w3id.org/np/RA8-bcgNHzty-3bdUqEaZSnWuP-J-UPW8bmcXSdeaYeJE/sample>;
    biolink:has_sequence_variant sub:variant .
}

sub:provenance {
  sub:assertion prov:wasDerivedFrom <https://w3id.org/mvikg/abox#VARIANT-VAR_001-P0DM78> .
}

sub:pubinfo {
  this: dct:created "2026-11-09T20:51:13Z"^^xsd:dateTime;
    dct:creator orcid:0009-0005-5515-1230;
    dct:license <https://creativecommons.org/licenses/by/4.0/>;
    npx:hasNanopubType npx:ExampleNanopub;
    npx:introduces sub:variant;
    nt:wasCreatedFromProvenanceTemplate <https://w3id.org/np/RA-yPZEYODCS39dWOWm7NA_ClOGFHzPi8iYhLzoZf19GI>;
    nt:wasCreatedFromPubinfoTemplate <https://w3id.org/np/RA4o9JqSxNO2Z47itbAcxvpVfdR97t_7usxmdR90URXQs>;
    nt:wasCreatedFromTemplate <https://w3id.org/np/RAnlONjGChImRjDeXxTwrTmndhfv1guES7EnXlp1CaE3g/templateVersion> .
  
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIIBIjANBgkqhkiG9w0BAQEFAAOCAQ8AMIIBCgKCAQEAjO3oH8Lq/l1oZIUY3FlCz5DnndybGvAhBdmEJ/yq7Nv3GZEYPrEro23rCBCp0GiriOXlVbk61pA/7JFE6tqzTresINW6QQMxE9sIhCBlX4cG66JFD8ud6bMvUyzCR8LQA6zfrSbafGE06rvglJd4MDUcTwvUKqtL9UCnOaowVfnZ3sPOe9EqlmJuO3iHGxBSXMPOPEJZUzMXsFDWFuMZTnrR8gY3r5nVF5a8L/MD135ZH8qW5yGXOB28CmVYCAbw2o07QEKzyzFKN+W1gfnprYZvuKzwGexnzcdzc1S8N/M5bzhWQ40EKCEqgUE8c81OzEMm1HUlUKEJ/o5I/FKKAwIDAQAB";
    npx:hasSignature "i4ugWDp3eTnc+AxK8ambtUo9zUGMS+zd86HhiwWPt00DOaO5XPMhoMMOvf+Gu9yZfQGiHpCEdfG9gyr2ZmGT7CkrIo+hfJZHJx1+3HrmAJLWEkY+xEz6okm+5HGFVaE8JmTXWRC1LZxns12hAaPhAsLdrDgv5FrLV0cij6/37loBfm2RpMNN6KKzshTOk1KPkHcaYI1dfk/xTmt1hTzIXjBZQqd37XMcUJy3TrO5EHIcTFjiuec/Qtpu/U2MaaJDKuTfrozmK6GfYB2QgsQvURd8nnI//T+w2TH/IzWjN518YR4Egd4MI7NM+ADShlOkf4qlL/G8/SCV5D+19nASAg==";
    npx:hasSignatureTarget this:;
    npx:signedBy orcid:0009-0005-5515-1230 .
}