[ { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#assertion", "@graph": [ { "@id": "http://purl.obolibrary.org/obo/DOID_1926", "https://w3id.org/biolink/vocab/category": [ { "@id": "https://w3id.org/biolink/vocab/Disease" } ] }, { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#association", "http://www.w3.org/1999/02/22-rdf-syntax-ns#object": [ { "@id": "http://purl.obolibrary.org/obo/DOID_1926" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate": [ { "@id": "https://w3id.org/biolink/vocab/treats" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject": [ { "@id": "https://identifiers.org/drugbank:DB09039" } ], "@type": [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://www.w3.org/2000/01/rdf-schema#label": [ { "@value": "cerdelga is indicated for the long term treatment of adult patients with gaucher disease type 1 gd1 who are cyp2d6 extensive metabolizers ems intermediate metabolizers ims or poor metabolizers pms as detected by an fda cleared test see dosage and administration 2 1 cerdelga is a glucosylceramide synthase inhibitor indicated for the long term treatment of adult patients with gaucher disease type 1 who are cyp2d6 extensive metabolizers ems intermediate metabolizers ims or poor metabolizers pms as detected by an fda cleared test 1 limitations of use cyp2d6 ultra rapid metabolizers may not achieve adequate concentrations of cerdelga to achieve a therapeutic effect 1 a specific dosage cannot be recommended for cyp2d6 indeterminate metabolizers 1 limitations of use patients who are cyp2d6 ultra rapid metabolizers urms may not achieve adequate concentrations of cerdelga to achieve a therapeutic effect see clinical studies 14 a specific dosage cannot be recommended for those patients whose cyp2d6 genotype cannot be determined indeterminate metabolizers see clinical studies 14" } ], "https://w3id.org/biolink/vocab/association_type": [ { "@id": "https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation" } ], "https://w3id.org/biolink/vocab/provided_by": [ { "@id": "https://w3id.org/um/NeuroDKG" } ], "https://w3id.org/biolink/vocab/relation": [ { "@id": "https://schema.org/TreatmentIndication" } ] }, { "@id": "https://identifiers.org/drugbank:DB09039", "https://w3id.org/biolink/vocab/category": [ { "@id": "https://w3id.org/biolink/vocab/Drug" } ] } ] }, { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#provenance", "@graph": [ { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#assertion", "http://www.w3.org/ns/prov#wasAttributedTo": [ { "@id": "https://orcid.org/0000-0002-1468-3557" } ] } ] }, { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#pubinfo", "@graph": [ { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#sig", "http://purl.org/nanopub/x/hasAlgorithm": [ { "@value": "RSA" } ], "http://purl.org/nanopub/x/hasPublicKey": [ { "@value": "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB" } ], "http://purl.org/nanopub/x/hasSignature": [ { "@value": "ETYCD+lirERQF6b0Ei6c6patvEaJ9gFUT+twB6KJmuH22oOL5L4gPyH1dr8AlkH0cpgLmmS+3ETBypfg4UhEKVBPVJ+dvSApBSa4po6WF7VI4BCSa+s2AfHwJQKxo2/wY32tV9erK/V/wwzt1vSIerAJz1gE78DgvqJU+A8hxqs=" } ], "http://purl.org/nanopub/x/hasSignatureTarget": [ { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4" } ] }, { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4", "http://purl.org/dc/terms/created": [ { "@value": "2021-06-12T14:23:10.024+02:00", "@type": "http://www.w3.org/2001/XMLSchema#dateTime" } ], "http://purl.org/dc/terms/creator": [ { "@id": "https://orcid.org/0000-0002-1468-3557" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate": [ { "@id": "http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate": [ { "@id": "http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate": [ { "@id": "http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs" } ] } ] }, { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#Head", "@graph": [ { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4", "http://www.nanopub.org/nschema#hasAssertion": [ { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance": [ { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo": [ { "@id": "http://purl.org/np/RAaNyCekmldrtbtpjnkO835gR_6Se5OpWFFrQfJT1UPx4#pubinfo" } ], "@type": [ "http://www.nanopub.org/nschema#Nanopublication" ] } ] } ]