@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RAcw80yPihjjkFEDE81KEM96Ke6QI0mrmQZPwRUyIg4Ho> .
@prefix sub: <http://purl.org/np/RAcw80yPihjjkFEDE81KEM96Ke6QI0mrmQZPwRUyIg4Ho#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix mondo: <http://purl.obolibrary.org/obo/MONDO_> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix efo: <http://www.ebi.ac.uk/efo/EFO_> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo .
}

sub:assertion {
  drugbank:DB00656 a biolink:Drug;
    rdfs:label "Trazodone";
    biolink:category biolink:Drug .
  
  mondo:0100081 a biolink:Disease;
    rdfs:label "sleep disorder";
    biolink:category biolink:Disease .
  
  sub:association a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    rdf:object mondo:0100081;
    rdf:predicate biolink:treats;
    rdf:subject drugbank:DB00656;
    rdfs:label "However, there are no sleep medications approved by the United States Food and Drug Administration and only one has been approved by the European Medicines Agency for pediatric insomnia; thus, most medications are prescribed off-label. Melatonin is widely used and safe in children with neurodevelopmental conditions. Gabapentin, clonidine, trazodone, and mirtazapine hold promise but require further study.";
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
    biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:context;
    biolink:publications pmid:31638842;
    biolink:relation ncit:C94303 .
  
  sub:context a biolink:Cohort;
    rdfs:label "Children";
    biolink:category biolink:Cohort;
    biolink:has_phenotype efo:0010642 .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
    npx:hasSignature "IOwk2FRs3bC0zA578MDgVy0ORDbzhBeF1bcWghXIgty//tAYkC61sELIrJGV6olWV3VrYUikM5hUQbLKQ3iyd3oyI1j1oWtBdhNvjtlaQyT8cBkZXVB5js+rN6+yrJPDQXxgpV86qXYJsLc9vTH1tS0tJOwNtX4h8F3tMtvvp0I=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2022-09-16T11:48:01.560262"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-1501-1082;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
  
  biolink: pav:version "2.3.0" .
}