http://purl.org/np/RAymPzHleRaxxoSGl85qjP2e8Xbx6kETXMYV-2rrvg59g
.trig | .trig.txt | .jelly | .jelly.txt
@prefix biolink: <https://w3id.org/biolink/vocab/> . @prefix ns1: <https://w3id.org/np/o/ntemplate/> . @prefix this: <http://purl.org/np/RAymPzHleRaxxoSGl85qjP2e8Xbx6kETXMYV-2rrvg59g> . @prefix sub: <http://purl.org/np/RAymPzHleRaxxoSGl85qjP2e8Xbx6kETXMYV-2rrvg59g#> . @prefix schema: <https://schema.org/> . @prefix np: <http://www.nanopub.org/nschema#> . @prefix dct: <http://purl.org/dc/terms/> . @prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix orcid: <https://orcid.org/> . @prefix prov: <http://www.w3.org/ns/prov#> . @prefix npx: <http://purl.org/nanopub/x/> . sub:Head { this: a np:Nanopublication; np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo . } sub:assertion { <http://purl.obolibrary.org/obo/DOID_437> biolink:category biolink:Disease . sub:association a rdf:Statement; rdf:object <http://purl.obolibrary.org/obo/DOID_437>; rdf:predicate biolink:treats; rdf:subject <https://identifiers.org/drugbank:DB00468>; rdfs:label "\"Quinine sulfate is contraindicated in patients with the following: Prolongation of QT interval ( 4 Glucose-6-phosphate dehydrogenase (G6PD) deficiency ( 4 Myasthenia gravis ( 4 Known hypersensitivity to quinine, mefloquine, or quinidine ( 4 Optic neuritis ( 4 Quinine sulfate is contraindicated in patients with the following: * Prolonged QT interval. One case of a fatal ventricular arrhythmia was reported in an elderly patient with a prolonged QT interval at baseline, who received quinine sulfate intravenously for P. falciparum [see WARNINGS AND PRECAUTIONS ( 5.3 * Glucose-6-phosphate dehydrogenase (G6PD) deficiency. * Hemolysis can occur in patients with G6PD deficiency receiving quinine. * Known hypersensitivity reactions to quinine. * These include, but are not limited to, the following [see WARNINGS AND PRECAUTIONS ( 5.6 * Thrombocytopenia * Idiopathic thrombocytopenia purpura (ITP) and Thrombotic thrombocytopenic purpura (TTP) * Hemolytic uremic syndrome (HUS) * Blackwater fever (acute intravascular hemolysis, hemoglobinuria, and hemoglobinemia) * Known hypersensitivity to mefloquine or quinidine: cross-sensitivity to quinine has been documented [see WARNINGS AND PRECAUTIONS ( 5.6 * Myasthenia gravis. Quinine has neuromuscular blocking activity, and may exacerbate muscle weakness. * Optic neuritis. Quinine may exacerbate active optic neuritis [see ADVERSE REACTIONS ( 6\""; biolink:provided_by <https://w3id.org/um/NeuroDKG>; biolink:relation schema:MedicalContraindication . <https://identifiers.org/drugbank:DB00468> biolink:category biolink:Drug . } sub:provenance { sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 . } sub:pubinfo { sub:sig npx:hasAlgorithm "RSA"; npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB"; npx:hasSignature "T3N3TGK5kHu+neLOtZXrtOnpSw3grcBqr1rVJrHngOeardHubJl2iz+jiYJ8cgDP9/IiglORHW1fpPFWcjjz+QIwrLDtmxl9ORr30gi+JcjE+QHuVh/QNeZCFlfK/GrE32Gig9oSpEvtA1qVESS+9oyxeuts3EJg0u9U+qdz2KY="; npx:hasSignatureTarget this: . this: dct:created "2021-08-23T18:44:18.224+02:00"^^xsd:dateTime; dct:creator orcid:0000-0002-1468-3557; ns1:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>; ns1:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>; ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> . }