Statement: Experimental Evidence - ΔcomK Phenotype
type: Nanopublication
has assertion: assertion
has provenance: provenance
has publication info: pubinfo
type: ExampleNanopub
created: 2026-01-11T23:26:00Z
license: https://creativecommons.org/licenses/by/4.0/
source: Natural Competence in Staphylococcus aureus
created by: Tiado Kollender
keywords: experimental evidence
keywords: mutant
keywords: survival
keywords: ΔcomK
was attributed to: Tiado Kollender

sig
has algorithm: RSA

DNA Mutations in Chromosome
type: GO_0006298
description: ROS causes serious damage and mutations in ΔcomK mutant DNA

Experimental Evidence for ComK Function
type: data 2603
BFO_0000050: DNA Mutations in Chromosome
BFO_0000050: No Glycolysis Increase in ΔcomK
BFO_0000050: Reduced Survival in Infection Models
BFO_0000050: Intracellular ROS Accumulation
description: ΔcomK competence-defective mutant shows impaired glycolysis and reduced survival

No Glycolysis Increase in ΔcomK
type: GO_0006096
description: ΔcomK mutant shows no increase in glycolysis under ROS exposure

Reduced Survival in Infection Models
type: GO_0008150
description: ΔcomK mutant shows significantly reduced survival in both mouse and Galleria infection models

Intracellular ROS Accumulation
type: GO_0019430
description: ROS accumulates inside ΔcomK mutant due to impaired respiration

Natural Competence in Staphylococcus aureus
type: AcademicArticle
doi: 10.1038/s41467-022-29206-7
date published: 2022