Statement: Experimental Evidence - ΔcomK Phenotype
ROS causes serious damage and mutations in ΔcomK mutant DNA
DNA Mutations in Chromosome
ΔcomK competence-defective mutant shows impaired glycolysis and reduced survival
Experimental Evidence for ComK Function
ΔcomK mutant shows no increase in glycolysis under ROS exposure
No Glycolysis Increase in ΔcomK
ΔcomK mutant shows significantly reduced survival in both mouse and Galleria infection models
Reduced Survival in Infection Models
ROS accumulates inside ΔcomK mutant due to impaired respiration
Intracellular ROS Accumulation
Natural Competence in Staphylococcus aureus